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Fig. 3. Kinetics of [11C]trimebutine in the brains of healthy rats. A. Repre sentative PET images of rats from 20 to 60 min after the injection of [11C]tri mebutine. Left: a control animal; Middle: animal injected with 10 mg/kg trimebutine prior to tracer injection; Right: animal treated with 2 mg/kg <t>cyprodime</t> prior to tracer injection. B. The time-activity curves of the tracer accumulation in the whole brain of control rats, rats injected with 10 mg/kg trimebutine, and rats injected with 2 mg/kg cyprodime.
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Fig. 3. Kinetics of [11C]trimebutine in the brains of healthy rats. A. Repre sentative PET images of rats from 20 to 60 min after the injection of [11C]tri mebutine. Left: a control animal; Middle: animal injected with 10 mg/kg trimebutine prior to tracer injection; Right: animal treated with 2 mg/kg <t>cyprodime</t> prior to tracer injection. B. The time-activity curves of the tracer accumulation in the whole brain of control rats, rats injected with 10 mg/kg trimebutine, and rats injected with 2 mg/kg cyprodime.
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Fig. 3. Kinetics of [11C]trimebutine in the brains of healthy rats. A. Repre sentative PET images of rats from 20 to 60 min after the injection of [11C]tri mebutine. Left: a control animal; Middle: animal injected with 10 mg/kg trimebutine prior to tracer injection; Right: animal treated with 2 mg/kg <t>cyprodime</t> prior to tracer injection. B. The time-activity curves of the tracer accumulation in the whole brain of control rats, rats injected with 10 mg/kg trimebutine, and rats injected with 2 mg/kg cyprodime.
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Fig. 3. Kinetics of [11C]trimebutine in the brains of healthy rats. A. Repre sentative PET images of rats from 20 to 60 min after the injection of [11C]tri mebutine. Left: a control animal; Middle: animal injected with 10 mg/kg trimebutine prior to tracer injection; Right: animal treated with 2 mg/kg <t>cyprodime</t> prior to tracer injection. B. The time-activity curves of the tracer accumulation in the whole brain of control rats, rats injected with 10 mg/kg trimebutine, and rats injected with 2 mg/kg cyprodime.
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Fig. 3. Kinetics of [11C]trimebutine in the brains of healthy rats. A. Repre sentative PET images of rats from 20 to 60 min after the injection of [11C]tri mebutine. Left: a control animal; Middle: animal injected with 10 mg/kg trimebutine prior to tracer injection; Right: animal treated with 2 mg/kg <t>cyprodime</t> prior to tracer injection. B. The time-activity curves of the tracer accumulation in the whole brain of control rats, rats injected with 10 mg/kg trimebutine, and rats injected with 2 mg/kg cyprodime.
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Fig. 3. Kinetics of [11C]trimebutine in the brains of healthy rats. A. Repre sentative PET images of rats from 20 to 60 min after the injection of [11C]tri mebutine. Left: a control animal; Middle: animal injected with 10 mg/kg trimebutine prior to tracer injection; Right: animal treated with 2 mg/kg cyprodime prior to tracer injection. B. The time-activity curves of the tracer accumulation in the whole brain of control rats, rats injected with 10 mg/kg trimebutine, and rats injected with 2 mg/kg cyprodime.

Journal: Nuclear Medicine and Biology

Article Title: PET imaging of the anticancer drug candidate [11C]trimebutine in a rat glioma model

doi: 10.1016/j.nucmedbio.2024.108985

Figure Lengend Snippet: Fig. 3. Kinetics of [11C]trimebutine in the brains of healthy rats. A. Repre sentative PET images of rats from 20 to 60 min after the injection of [11C]tri mebutine. Left: a control animal; Middle: animal injected with 10 mg/kg trimebutine prior to tracer injection; Right: animal treated with 2 mg/kg cyprodime prior to tracer injection. B. The time-activity curves of the tracer accumulation in the whole brain of control rats, rats injected with 10 mg/kg trimebutine, and rats injected with 2 mg/kg cyprodime.

Article Snippet: Cyprodime hydrochloride was purchased from ToCris (Bio-Techne Ltd., Abingdon, United Kingdom).

Techniques: Injection, Control, Activity Assay